This meeting has reached its capacity.
On-site registration is not available.
Twelfth International Workshop
On Molecular Aspects Of Myeloid Stem Cell Development And Leukemia
May 7-10, 2018
Cincinnati Children's Hospital
Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229
ABOUT
Since 1995, the Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia has offered a highly successful presentation series from approximately 40-50 renowned national and international researchers and clinicians.
The goal of these biennial workshops is to bring together investigators with expertise in complementary aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemia and myelodysplastic/myeloproliferative syndromes. Basic researchers and clinician investigators from both sides of the Atlantic, Australia, and Japan come together biennially to discuss their latest findings in a close and informal setting. The workshop brings together scientists with expertise in normal and abnormal hematopoiesis and clinicians who treat leukemia/MDS/MPD patients and also have active research programs in these diseases.
Participants achieve a better understanding of critical steps/factors that regulate hematopoiesis, their impact on leukemogenesis, and their potential relevance in clinical settings. Although there are other workshops and meetings dedicated to understanding the regulation of hematopoiesis or clinical advances in leukemia, this workshop uniquely brings together both clinicians and scientists in a relaxed forum.
Speakers
Abdel-Wahab, Omar
Memorial Sloan Kettering
Aifantis, Iannis
New York University
Abkowitz, Janis
University of Washington
Bonifer, Constanze
University of Birmingham, UK
Bresnick, Emery
University of Wisconsin
Carlesso, Nadia
City of Hope
Carroll, Martin
University of Pennsylvania
Castilla, Lucio
University of Massachusetts
Cheng, Tao
State Key Laboratory of Experimental Hematology, Tianjin,China
Crispino, John
Northwestern University
Delwel, Ruud
Erasmus University, the Netherlands
Figueroa, Maria
University of Miami
Filippi, Marie-Dominique
Cincinnati Children’s Hospital
Frenette, Paul
Albert Einstein College of Medicine
Godley, Lucy
University of Chicago
Goldfarb, Adam N.
University of Virginia
Goodell, Peggy
Baylor College of Medicine
Gottgens, Bertie
Cambridge University UK
Graubert, Tim
Massachusetts General Hospital
Grimes, H. Leighton
Cincinnati Children's Hospital
Guzman, Monica
Weill Cornell
Singh, Harinder
Cincinnati Children’s Hospital
Hiebert, Scott
Vanderbilt University
Horwitz, Marshall
University of Washington
Huang, Gang
Cincinnati Children's Hospital
Kalfa, Theodosia
Cincinnati Children's Hospital
Kharas, Michael
Memorial Sloan Kettering
Krause, Diane
Yale University
Le Beau, Michelle
University of Chicago
Levine, Ross
Memorial Sloan Kettering
Link, Dan
Washington University School of Medicine
List, Alan
Moffitt Cancer Center
Lucas, Daniel
Cincinnati Children’s Hospital
Majeti, Ravi
Stanford University
Melnick, Ari
Weill Cornell
Milsom, Michael
German Cancer Research Center, Germany
Moore, Kateri
Mount Sinai, New York
Murphy Kenneth
Washington University
Nerlov, Claus
University of Oxford, UK
Nimer, Stephen
University of Miami
Novina, Carl
Dana Farber
Papapetrou, Eirini
Mount Sinai
Passegue, Emmanuelle
Columbia University
Sauvageau, Guy
University of Montreal, Canada
Schroeder, Timm
ETH Zurich, Switzerland
Shimamura, Akiko
Harvard University
Starczynowski, Daniel
Cincinnati Children's Hospital
Stegmaier, Kim
Dana-Farber Cancer Institute
Steidl, Uli
Albert Einstein College of Medicine
Tenen, Dan
Harvard/CSI Singapore
Touw, Ivo
Erasmus University, the Netherlands
Trumpp, Andreas
German Cancer Research Center, Germany
Vyas, Paresh
University of Oxford, UK
Wang, Qianfei "Jeffrey"
Beijing Institute of Genomics, China
Xu, Jian
UT Southwestern
Zhang, Dong-Er
University of California, San Diego
AGENDA
Monday, May 7th
6:00–7:30 AM
Breakfast at the 21C Hotel
“COUNTRY PICNIC BREAKFAST”
7:20 AM
BUS 1, Transportation to Cincinnati Children’s
7:30 AM
BUS 2, Transportation to Cincinnati Children’s
7:40 AM
BUS 3, Transportation to Cincinnati Children’s
CCHMC S1.203-204
8:00 AM to 1:00 PM
Session Chairs: Lionel Blanc and Punam Malik
8:00 AM
Emery Bresnick, University of Wisconsin-Madison
GATA Factor/Heme Multi-omics Reveals a Trace Metal-Dependent
Cellular Differentiation Mechanism
8:30 AM
John Crispino, Northwestern University
A CHAF1B-dependent molecular switch in hematopoiesis and leukemia
9:00 AM
Theodosia Kalfa, CCHMC
The Erythro-Myeloblastic Island: A Hematopoietic Niche Balancing Erythropoiesis and Myelopoiesis
9:30 AM
Diane Krause, Yale University
Role of the cell cycle in megakaryocyte-erythroid progenitor fate specification
10:00 AM
Jan Abkowitz, University of Washington
Heme-globin dyscoordination and the pathogenesis of macrocytic anemia in MDS
10:30 AM
Break
11:00 AM
Tim Graubert, Mass General Hospital
Spliceosomal Mutations Induce R Loop-Associated ATR Signaling
11:30 AM
Stephen Nimer, University of Miami
Alteration of RUNX1 Function by Chromosomal Translocations or Protein-Protein Interactions
12:00 PM
Omar Abdel-Wahab, MSKCC
Convergent Effects of MDS-Associated Spliceosomal Gene Mutations on Innate Immune Signaling and Inflammation
12:30 PM
Gang Huang, CCHMC
Pseudohypoxia as a Common Mechanism Underlying Myelodysplastic Syndromes
1:00 PM
Lunch
“LEMONADE: LUNCH IN LOS ANGELES”
2:00 PM to 5:00 PM
Session Chairs: Ken Figueroa and Michelle Le Beau
2:00 PM
Uli Steidl, Albert Einstein College of Medicine
MDS Progression to AML at the Stem Cell Level
2:30 PM
Alan List, Moffit Cancer Center
Autologous DNA Exposure Activates Innate Immune Axes in MDS
3:00 PM
Emmanuelle Passegue, Columbia University
Inflammaging - a cross-talk between two aging systems: stroma and blood
3:30 PM
Break
“PERFECT PROFITEROLES”
4:00 PM
Michael Milsom, DKZF-Heidelberg, Germany
Inflammatory stress fails to impact HSC numbers but drives their progressive and irreversible functional decline
4:30 PM
Daniel Lucas, CCHMC
An endothelial niche uncouples emergency granulopoiesis from bone marrow suppression
LIGHTNING ROUND
Session Chair: Dan Tenen
5:00 PM
Terry Rogers Bishop, NIDDK
Funding Opportunities from the NIDDK at NIH
5:05 PM
Hideyo Hirai, Kyoto University, Japan
C/EBPb isoforms sequentially regulate the proliferation and differentiation of regenerating hematopoietic stem/progenitor cells.
5:10 PM
Claudia Waskow, Friedrich Schiller University, Germany
Cross-talk between embryonic and adult hematopoiesis
5:15 PM
Jan-Henning Klusman, Martin-Luther University Halle-Wittenberg, Germany
Modeling the progression of a preleukemic stage to overt leukemia in children with Down Syndrome.
5:20 PM
Grant Challen, Washington University in St. Louis
Jarid2 restricts self-renewal capacity in hematopoietic progenitors and is a tumor suppressor in chronic myeloid neoplasms.
5:25 PM
Greg Wang, University of North Carolina at Chapel Hill
Epigenetic regulation of myeloid malignancy
5:30 PM
Andrew Muntean, University of Michigan at Ann Arbor
A novel PAF1c-SETDB1 interaction mediates H3K9 methylation of pro-leukemic genes and suppresses leukemogenesis.
5:35 PM
David Wiest, Fox Chase Cancer Center
Ribosomal protein control of hematopoietic stem cell transformation through regulation of a lipoxygenase.
5:40 PM
Goro Sashida, Kumamoto University, Japan
Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm.
5:45 PM
Megan McNerney, University of Chicago
Murine CUX1 reduction disrupts HSC homeostasis and controls the severity and mortality of MDS in a dose-dependent manner.
5:50 PM
Jenn Trowbridge, The Jackson Laboratory
Npm1-ca overcomes the differentiation block of Dnmt3a-mutant LT-HSC to transition bone marrow failure to myeloproliferative.
5:55 PM
Brad Blaser, The Ohio State University Comprehensive Cancer Center
Enforced expression of cxcl8 by hematopoietic stem and progenitor cells increases endothelial cell cuddling and expands hematopoietic progenitor cells in adult zebrafish.
6:00 PM
Stephanie Xie, Princess Margaret Cancer Center, Toronto, Canada
Sphingolipids govern the myeloid commitment of human hematopoietic and leukemic stem cells.
6:15 PM
Transportation to The American Signs Museum
1330 Monmouth Ave, Cincinnati, OH 45225 (NOT Monmouth Ave. in Kentucky)
6:30–9:30 PM
Tuesday, May 8th
6:00–7:30 AM
Breakfast at the 21C Hotel
“POWER BREAKFAST BUFFET”
7:20 AM
BUS 1, Transportation to Cincinnati Children’s
7:30 AM
BUS 2, Transportation to Cincinnati Children’s
7:40 AM
BUS 3, Transportation to Cincinnati Children’s
CCHMC S1.203-204
8:00 AM to 12:30 PM
Session Chairs: Jose Cancelas and Iannis Aifantis
8:00 AM
Adam Goldfarb, University of Virginia School of Medicine
Human HSPC Dysregulation of RUNX3 in MDS and Normal Aging May Contribute to Perturbations in Lineage Output
8:30 AM
Andreas Trumpp, DKFZ-Heidelberg, Germany
Hematopoietic Stem Cells Are Regulated by Alternative Polyadenylation
9:00 AM
Ken Figueroa, University of Miami
Epigenetic Reprogramming of Enhancer and Regulatory Elements During Aging of human HSCs
9:30 AM
Marie Dominique Filippi, CCHMC
Mitochondria determine the lifespan of hematopoietic stem cells
10:00 AM
Nadia Carlesso, City of Hope
Defective Notch activation in mesenchymal cells cooperates with aging in the development of myeloid neoplasms
10:30 AM
Break
11:00 AM
Timm Schroeder, ETH Zurich, Switzerland
Hematopoiesis at single-cell and single-molecule resolution
11:30 AM
Iannis Aifantis, NYU
Profiling the bone marrow microenvironment at single-cell resolution
12:00 PM
Paul Frenette, Albert Einstein College of Medicine
Adrenergic nerve degeneration of the aging bone marrow niche reprograms HSCs to exhibit myeloid cell differentiation bias and other aging characteristics
12:30 PM
Lunch
“LEE'S LUNCH”
1:30 PM to 6:00 PM
Session Chairs: Akiko Shimamura and Ivo Touw
1:30 PM
Kateri Moore, Icahn School of Medicine at Mt. Sinai
Induction of a Hemogenic Program in Mouse Fibroblasts
2:00 PM
Eirini Papapetrou, Icahn School of Medicine at Mt. Sinai
Studying the biology and therapeutic vulnerabilities of leukemia stem cells using patient-derived iPSC models
2:30 PM
Akiko Shimamura, Boston Children’s Hospital
iPSC model of bone marrow failure and MDS identifies a novel therapeutic strategy.
3:00 PM
Carl Novina, Dana-Farber Cancer Institute
Activated TGFb signaling in early hematopoietic progenitors promotes bone marrow failure in Shwachman-Diamond Syndrome
3:30 PM
Dan Link, Washington University in St. Louis
Regulation of the hematopoietic niche by TGF-β signaling
4:00 PM
Break
“FREAKcakes”
4:30 PM
Marshall Horwitz, University of Washington
Targeting Transcription Factors in Familial and Sporadic Leukemia
5:00 PM
Lee Grimes, CCHMC
Mouse modeling of severe congenital neutropenia-associated mutations
5:30 PM
Ivo Touw, Erasmus University Medical Center, The Netherlands
Modeling leukemic progression of severe congenital neutropenia in iPSC.
6:15 PM
Transportation to the Cincinnati Contemporary Arts Center
44 E. 6th St., Cincinnati, OH 45202
6:30–9:30 PM
Wednesday, May 9th
6:30–7:30 AM
Breakfast at the 21C Hotel
“QUEEN CITY HOT BREAKFAST”
7:20 AM
BUS 1, Transportation to Cincinnati Children’s
7:30 AM
BUS 2, Transportation to Cincinnati Children’s
7:40 AM
BUS 3, Transportation to Cincinnati Children’s
CCHMC S1.203-204
8:00 AM to 1:00 PM
Session Chairs: Harinder Singh and Ari Melnick
8:00 AM
Harinder Singh, CCHMC
Using integrative genomics to reveal the functional enhancer landscape of activated B cells.
8:30 AM
Ken Murphy, Washington University in St. Louis
Development of dendritic cell subsets
9:00 AM
Bertie Gottgens, Cambridge University, UK
Capturing Dynamic Changes in Haematopoietic Differentiation Landscapes
9:30 AM
Dong-Er Zhang, University of California, San Diego
Hippo kinase deficiency cooperates with JAK2(V617F) to promote myeloproliferative neoplasm progression in mice
10:00 AM
Jian Xu, University of Texas Southwestern
Loss of EZH2 Activates BCAA Metabolism to Drive Myeloid Transformation
10:30 AM
Break
11:00 AM
Conny Bonifer, University of Birmingham, UK
Subtype-specific regulatory network rewiring in acute myeloid leukemia
11:30 AM
Tao Cheng, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Reprogramming Factors Preferentially Kill Leukemia Cells as Opposed to Normal Hematopoietic Cells
12:00 PM
Peggy Goodell, Baylor College of Medicine
Mutant NPM1 maintains the leukemic state through HOX expression
12:30 PM
Lunch
“OHIO FARMSTAND”
2:00 PM to 6:30 PM
Session Chairs: Daniel Starczynowski and Ross Levine
1:30 PM
Ruud Delwel, Erasmus University, The Netherlands
Oncoprotein enhancer hijacking reverses active chromatin state and deregulates gene expression and topology
2:00 PM
Claus Nerlov, University of Oxford, England
Myelo-erythroid progenitors and leukemias
2:30 PM
Martin Carroll, U Penn
Combinatorial Proteomics Analysis Demonstrates FLT3 Regulation of EZH2 expression
3:00 PM
Ari Melnick, Weill Cornell Medicine
Genetically-defined AML Subgroups Represent Diverse Epigenetic Allelic Heterogeneity Landscape
3:30 PM
Break
“HIGH tea”
4:00 PM
Guy Sauvageau, University of Montreal, Canada
Identification of an Electron Transport Chain Vulnerability in Acute Myeloid Leukemia
4:30 PM
Kim Stegmaier, Dana-Farber Cancer Institute
Emerging Targets in AML through Functional Genomic Screens
5:00 PM
Dan Tenen, Harvard and Cancer Institute of Singapore
New therapeutics targeting the CEBPA pathway in Acute Myeloid Leukemia
5:30 PM
Daniel Starczynowski, CCHMC
U2AF1 mutations induce oncogenic innate immune pathways by regulating the expression of active IRAK4 isoforms in AML and MDS
6:15 PM
Transportation to 21C Hotel
6:30–8:00 PM
POSTER SESSION
8:00 PM
dinner on your own
Thursday, May 10th
6:30–7:30 AM
Breakfast at the 21C Hotel
“POWER BREAKFAST BUFFET”
7:20 AM
BUS 1, Transportation to Cincinnati Children’s
7:30 AM
BUS 2, Transportation to Cincinnati Children’s
7:40 AM
BUS 3, Transportation to Cincinnati Children’s
CCHMC S1.203-204
2:00 PM to 6:30 PM
Session Chairs: Steven Gore
8:00 AM
Paresh Vyas, University of Oxford, UK
The clonal basis of AML therapy response and resistance to enasidenib.
8:30 AM
Ross Levine, MSKCC
Role of mutations in epigenetic regulators in the pathogenesis of AML
9:00 AM
Qian-Fei Wang, Beijing Institute of Genomics, China
Precision Medicine and Clonal Evolution in Children with Acute Myeloid Leukemia Treated with Low-Dose Chemotherapy plus G-CSF for Remission Induction
9:30 AM
Ravi Majeti, Stanford University
Metabolic Differences between IDH1 and IDH2 Mutant Acute Myeloid Leukemia Yield Therapeutic Vulnerabilities
10:00 AM
Break
10:30 AM
Lucio Castilla, U Mass Worchester
CBFβ-SMMHC/RUNX1 Regulate MYC Expression by Modulating Chromatin Dynamics at Distal Enhancers in Inv(16) Leukemia
11:00 AM
Michael Kharas, MSKCC
Towards therapeutic targeting of the MUSASHI RNA binding protein network
11:30 AM
Scott Hiebert, Vanderbilt
Targeting Histone Modifying Enzymes in t(8;21) AML
12:00 PM
Monica Guzman, Weill Cornell Medicine
Novel Organoid-Like Culture System to Evaluate Leukemia Stem Cells
12:30 PM
Box Lunch
“PLOUGHMAN'S LUNCH”
1:00 PM and 1:30 PM
Transportation to CVG or 21C Hotel
SUBMIT ABSTRACT
All abstracts should follow the ASH (American Society of Hematology) format guidelines.
All abstracts should be submitted in Arial, 11-point font with one-inch margins all around.
Posters should be 3ft x 6ft.
All abstracts must be submitted by March 1st, 2018.
Email abstracts to Erin Davis.
[email protected]
HOTEL
21c Museum Hotel, Cincinnati
609 Walnut Street
Cincinnati, Ohio 45202
(513) 578-6600
The hotel is full and no longer accepting reservations in the Myeloid18 block.
Room Pricing
$189.00 Single/Double
Room occupancy rate plus 17.5% applicable state and local taxes.
SPONSORS
AMERICAN SIGN MUSEUM
Come take a walk down Memory Lane and experience the only public sign museum in America. Visit the American Sign Museum and find a treasure trove of information relative to the rich tradition of sign fabrication and design. You can also find news of sign preservation efforts throughout the country and even visit the Museum's permanent collection.
EXPLORE CINCINNATI
The CAC is one of the first contemporary art institutions in the United States. It is a pioneering contemporary art museum located in Cincinnati, Ohio. The CAC is a non-collecting museum that focuses on new developments in painting, sculpture, photography, and more.
The Cincinnati Art Museum is one of the oldest art museums in the United States. Founded in 1881, it was the first purpose-built art museum west of the Alleghenies. Its collection of over 60,000 works makes it one of the most comprehensive collections in the Midwest.
The Cincinnati Zoo and Botanical Garden is one of the oldest zoos in the United States. It opened in 1875, just 14 months after the Philadelphia Zoo on July 1st, 1874. The Reptile House is the oldest zoo building in the United States, dating from 1875.
Learn about the history of the river, take in a magnificent meal, or dance under the stars on an unbelievable journey you will never forget. BB Riverboats offers a wide variety of cruises, ranging from lunch and dinner cruises to sightseeing cruises and all-day mini vacations.
The Cincinnati Museum Center at Union Terminal is a passenger railroad station in the Queensgate neighborhood of Cincinnati. After the decline of railroad travel, most of the building was converted to other uses, and now houses museums, theaters, and more.
Fountain Square attracts over 2 million people annually to its special events, free concerts, tailgates, and lunchtime contests. It’s a place to meet friends for morning coffee or gather for lunch. A place to learn about Cincinnati's history and begin or end your evening downtown.
Pyramid Hill is an outdoor museum focusing on monumental pieces of sculpture in an environment of meadows, forests, and various gardens. They also feature a 10,000-square-foot Ancient Sculpture Museum displaying Egyptian, Greek, Roman, and Etruscan sculptures thousands of years old.
The Taft Museum of Art is one of the finest small art museums in America. A National Historic Landmark built in 1820, the Taft is home to an extensive art collection that includes European and American master paintings, Chinese porcelains, and European decorative arts.
CONTACT
Scientific Issues
H. Leighton Grimes PhD
Phone: (513) 636-6089
Email: [email protected]
Logistic Issues
Erin Davis
Phone: (513) 803-2152
[email protected]
Danielle Davis
Phone: (513) 636-1773
[email protected]
