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ELEVENTH INTERNATIONAL WORKSHOP
ON MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT AND LEUKEMIA
May 2 - 5, 2016
Cincinnati Children's Hospital
Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229
ABOUT
Since 1995, the Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia has offered a highly successful presentation series from approximately 40-50 renowned national and international researchers and clinicians.
The goal of these biennial workshops is to bring together investigators with expertise in complementary aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemia and myelodysplastic/myeloproliferative syndromes. Basic researchers and clinician investigators from both sides of the Atlantic, Australia, and Japan come together biennially to discuss their latest findings in a close and informal setting. The workshop brings together scientists with expertise in normal and abnormal hematopoiesis and clinicians who treat leukemia/MDS/MPD patients and also have active research programs in these diseases.
Participants achieve a better understanding of critical steps/factors that regulate hematopoiesis, their impact on leukemogenesis, and their potential relevance in clinical settings. Although there are other workshops and meetings dedicated to understanding the regulation of hematopoiesis or clinical advances in leukemia, this workshop uniquely brings together both clinicians and scientists in a relaxed forum.
SPEAKERS
Abkowitz, Jan
Division of Hematology
Aifantis, Iannis
New York University
Amit, Ido
Weizmann Institute, Israel
Aplan, Peter
National Cancer Institute
Azam, Mohammad
Cincinnati Children's Hospital Medical Center
Bresnick, Emery
University of Wisconsin
Cancelas, Jose
Cincinnati Children's Hospital Medical Center
Carlesso, Nadia
Indiana University
Carroll, Martin
University of Pennsylvania
Castilla, Lucio
University of Massachusetts Medical School
Corey, Seth
Northwestern University
Crispino, John
Northwestern University
Delwel, Ruud
Erasmus University, Netherlands
Ebert, Ben
Harvard Medical School
Ernst, Patricia
University of Colorado, Denver
Figueroa, Maria
University of Michigan
Friedman, Alan
Johns Hopkins University
Godley, Lucy
University of Chicago
Goldfarb, Adam
University of Virginia, School of Medicine
Goodell, Margaret A.
Baylor College of Medicine
Graubert, Timothy A.
Massachusetts General Hospital
Grimes, H. Leighton
Cincinnati Children's Hospital Medical Center
Halene, Stephanie
Yale School of Medicine
Hiebert, Scott
Vanderbilt University School of Medicine
Horwitz, Marshall
University of Washington School of Medicine
Huang, Gang
Cincinnati Children's Hospital Medical Center
Iwama, Atsushi
Chiba University, Japan
Jordan, Craig
University of Colorado, Anschutz Medical Campus
Kharas, Michael
Memorial Sloan Kettering
Krause, Diane
Yale University School of Medicine
Le Beau, Michelle
University of Chicago
Link, Daniel
Washington University School of Medicine
List, Alan F.
Moffitt Cancer Center
Levine, Ross
Memorial Sloan Kettering
Melnick, Ari
Weill Cornell Medicine
Mulloy, James
Cincinnati Children's Hospital Medical Center
Natoli, Gioacchino
IFOM-IEO, Italy
Nimer, Stephen
University of Miami School of Medicine
Papapetrou, Eirini
Icahn School of Medicine at Mount Sinai
Park, Chris
Memorial Sloan Kettering
Passegue, Emmanuelle
University of California, San Francisco
Rosmarin, Alan
University of Massachusetts Medical School, Worcester
Reynaud, Damien
Cincinnati Children's Hospital Medical Center
Shimamura, Akiko
Fred Hutchinson Cancer Center
Singh, Harinder
Cincinnati Children's Hospital Medical Center
Smale, Stephen
University of California, Los Angeles
Starczynowski, Daniel
Cincinnati Children's Hospital Medical Center
Stegmaier, Kim
Harvard Medical School
Steidl, Uli
Albert Einstein College of Medicine
Tenen, Daniel
Harvard Medical School
Touw, Ivo
University, Netherlands
Trumpp, Andreas
German Cancer Research Center, Germany
Vyas, Paresh
Radcliffe Department of Medicine
Zon, Leonard
Boston Children's Hospital
AGENDA
Monday, May 2nd
7:30 AM
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
EPIGENETICS
Chairs: James C. Mulloy and Maria E. Figueroa
8:00 AM
Expression of a NUP98-HOXD13 fusion gene and IDH2 R140Q mutant leads to early T-cell precursor (ETP) leukemia
Peter D. Aplan
NCI/NIH
8:30 AM
Polycomb repressive complexes in hematological malignancies
Atsushi Iwama
Chiba University, Japan
9:00 AM
A Faithful In Vivo Model of Human MLL-AF4 pro-B Acute Lymphoblastic Leukemia
James C. Mulloy
Cincinnati Children’s Hospital Medical Center
9:30 AM
Applying lessons learned from inherited forms of leukemia in order to treat ALL: Addressing haploinsufficiency of PAX5 through activation of functionally equivalent gene family members
Marshall Horwitz
University of Washington, Seattle
10:00 AM
High-Resolution Mapping of Active RNA Polymerases Defines the Mechanism of Action of Chromatin Regulators in t(8;21) AML
Scott W. Hiebert
Vanderbilt University
10:30 AM
Break
11:00 AM
Role of mutations in epigenetic regulators in the pathogenesis of myeloid malignancies
Ross Levine
Memorial Sloan Kettering
12:00 PM
Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia
Sara E. Meyer
Cincinnati Children’s Hospital Medical Center
12:30 PM
The role of 5-hydroxymethylcytosine in epigenetic regulation of myelodysplastic syndromes
Maria E. Figueroa
University of Michigan
1:00 PM
TARGETS IN HEMATOLOGIC MALIGNANCIES
Chair: Patricia Ernst
2:00 PM
MUSASHI-2 and the RNA binding network in myeloid leukemia
Michael Kharas
Memorial Sloan Kettering
2:30 PM
Transcriptional Dysregulation in Pre-Leukemic Stem Cells and their Progression to MDS and AML
Ulrich Steidl
Albert Einstein College of Medicine
3:00 PM
Core circadian clock genes regulate leukemia stem cells in AML
Benjamin Ebert
Harvard Medical School
LIGHTNING ROUND: rapid fire 4-minute talks with one slide (selected from the posters)
Chair: Dan Tenen (and a rubber chicken)
Daniel Lucas-Alcoraz
Bone marrow granulocytes drive hematopoietic and vascular regeneration
Karen Sue Carlson
Extracellular Matrix Homeostasis Can Regulate Steady-State Hematopoiesis
Joseph Fisher
The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA9
Hironori Harada
Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes
Jan Henning Klusmann
Integrated Analysis of the Human Hematopoietic Non-Coding RNA Landscape Reveals Lnc-RNA Stem Cell Signature in AML
Scott Kogan
A tumor suppressive role of IRF8 in acute promyelocytic leukemia
Ivan Maillard
Ash1l, the mammalian homolog of a Trithorax group gene, controls hematopoietic stem cell homeostasis independently of its methyltransferase activity.
Andrew Munteen
Differential regulation of c-Myc/Lin28 discriminates subclasses of rearranged MLL leukemia.
Tobias Neff
The Role of Gata2 in Murine Models of Acute Myeloid Leukemia
David Sykes
Small molecule inhibitors of the enzyme dihydroorotate dehydrogenase overcome differentiation blockade in acute myeloid leukemia.
Michael Thirman
Transducible MLL peptide exhibits significant activity in combination with DOT1L and CDK9 inhibitors.
Jennifer Trowbridge
Acute Myeloid Leukemia (AML) Cell-of-Origin Identified by Chromatin Landscape of Bulk Tumor Cells
CCHMC S1.203-204
HEMATOPOIETIC DIFFERENTIATION AND LINEAGE COMMITMENT
Chair: Harinder Singh
8:00 AM
Role of the +37 kb Cebpa Enhancer During Hematopoiesis and Myeloid Transformation
Alan Friedman
Johns Hopkins University
8:30 AM
An exclusive CEBPA enhancer for myeloid-lineage priming and neutrophilic differentiation
Ruud Delwel
ErasmusMC, The Netherlands
9:00 AM
Regulation of the tumor suppressor CEBPA by non-coding RNA
Daniel G. Tenen
Cancer Science Institute of Singapore
9:30 AM
An Ontogenic Molecular Switch Controls Human Megakaryocyte Differentiation by Modulating a Specialized P-TEFb Activation Pathway
Adam N. Goldfarb
University of Virginia
10:00 AM
Targeting aberrant megakaryopoiesis in primary myelofibrosis
John Crispino
Northwestern University
10:30 AM
Break
2:30 PM
Induction of Key Immunoregulatory Genes in Macrophages by Highly Unique Molecular Mechanisms
Stephen T. Smale
UCLA
3:00 PM
Cis-Regulatory Mechanisms Governing Hematopoietic Stem and Progenitor Cell Transitions
Emery H. Bresnick
Wisconsin School of Medicine
MARROW FAILURE AND TRANSFORMATION
Chair: Akiko Shimamura
3:30 PM
Molecular Aspects of Myeloid Stem Cell Development
Stephen Nimer, MD
Sylvester Comprehensive Cancer Center, University of Miami
4:00 PM
Modeling leukemic progression of severe congenital neutropenia (SCN) by genome editing of patient-derived induced pluripotent stem cells
Ivo Touw
Erasmus MC, The Netherlands
4:30 PM
Break "Southern Gentleman"
5:00 PM
Modeling Bone Marrow Failure and MDS in Shwachman Diamond Syndrome using induced Pluripotent Stem Cells
Akiko Shimamura
Boston Children's Cancer
Wednesday, May 4th
7:30 AM
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
HEMATOPOIETIC STEM CELLS
Chair: Iannis Aifantis
8:00 AM
Hijacking of emergency myelopoiesis pathways in myeloid malignancies
Emmanuelle Passegué
UCSF
8:30 AM
Gfi1 Contributes to the Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity
Damien Reynaud
Cincinnati Children's Hospital Medical Center
9:00 AM
Regulation of hematopoietic stem cell enhancer dynamics by the MEDIATOR complex
Iannis Aifantis
NYU School of Medicine
9:30 AM
Control of Dormancy in HSCs by Myc and Retinoic Acid
Andreas Trumpp
German Cancer Research Center
12:30 PM
MDS MODELING AND THERAPY
Chair: Daniel Starczynowski
1:30 PM
Epistasis of neighboring immune-requisite genes in del(5q) MDS
Daniel Starczynowski, PhD
Cincinnati Children’s Hospital Medical Center
2:00 PM
Modeling Therapy-Related Myeloid Neoplasms with a del(5q): Haploinsufficiency of Multiple del(5q) Genes Cooperate with loss of TP53 and Alkylating Agent Therapy
Michelle Le Beau
University of Chicago
2:30 PM
Targeting MDS Stem Cell with Novel TLR Selective Therapeutics
Alan F. List
Moffitt Cancer Center
3:00 PM
Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model
Stephanie Halene
Yale University
3:30 PM
Break "Dr. Figueroa’s Demand"
Poster Session
Sponsored by the Evans Foundation
21c Gallery open bar and Dinner-By-The-Bite
Thursday, May 5th
7:30 AM
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
TARGETING LEUKEMIA
Chairs: Ari Melnick and Craig T. Jordan
8:00 AM
Mechanism of BCR-ABL addiction and TKI efficacy
Mohammad Azam
Cincinnati Children’s Hospital Medical Center
8:30 AM
Therapeutic Targeting of the Leukemic Stem Cell in Chronic Myelogenous Leukemia and a Novel Approach to Overcome Resistance to Tyrosine Kinase Inhibitors
Alan G. Rosmarin
University of Massachusetts Medical School Worcester
9:00 AM
Mechanism of AI-10-49 mediated apoptosis in inv16 AML
Lucio H. Castilla
University of Massachusetts Medical School, Worcester
9:30 AM
Gene repression by DNA methylation and LSD1-mediated enhancer inactivation in AML
Ari Melnick
Cornell University
Inflammation recruits progenitors directly to lymphatics for dendritic cell replenishment through CCR7 and non-canonical IkB kinase
Jose A. Cancelas
Cincinnati Children’s Hospital Medical Center
12:30 PM
1:30 PM
Shuttle to the CVG airport
2:00 PM
Shuttle to 21c Museum Hotel and then CVG airport
SUBMIT ABSTRACT
All abstracts should follow the ASH (American Society of Hematology) format guidelines.
All abstracts should be submitted in Arial, 11-point font with one-inch margins all around.
Posters should be 3ft x 6ft.
All abstracts must be submitted by April 1st, 2016.
Email abstracts to Kristie Gilb at [email protected].
HOTEL
21c Museum Hotel Cincinnati
609 Walnut Street
Cincinnati, Ohio 45202
(513) 578-6600
When making your reservation, please state that you are part of the MYELOID WORKSHOP Group; otherwise, the 21c staff will not be able to provide the negotiated rates. The last date to make reservations at the negotiated rate is Thursday, March 31st, 2016.
Room Pricing
$189.00 Single/Double
Room occupancy rate plus 17.5% applicable state and local taxes.
SPONSORS
AMERICAN SIGN MUSEUM
Come take a walk down Memory Lane and experience the only public sign museum in America. Visit the American Sign Museum and find a treasure trove of information relative to the rich tradition of sign fabrication and design. You can also find news of sign preservation efforts throughout the country and even visit the Museum's permanent collection.
EXPLORE CINCINNATI
The CAC is one of the first contemporary art institutions in the United States. It is a pioneering contemporary art museum located in Cincinnati, Ohio. The CAC is a non-collecting museum that focuses on new developments in painting, sculpture, photography, and more.
The Cincinnati Art Museum is one of the oldest art museums in the United States. Founded in 1881, it was the first purpose-built art museum west of the Alleghenies. Its collection of over 60,000 works makes it one of the most comprehensive collections in the Midwest.
The Cincinnati Zoo and Botanical Garden is one of the oldest zoos in the United States. It opened in 1875, just 14 months after the Philadelphia Zoo on July 1st, 1874. The Reptile House is the oldest zoo building in the United States, dating from 1875.
CONTACT
Scientific Issues
H. Leighton Grimes PhD
Phone: (513) 636-6089
Email: [email protected]
Logistic Issues
Kristie Gilb
Phone: (513) 636-9445
Email: [email protected]
Danielle Davis
Phone: (513) 636-1773
Email: [email protected]