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TENTH INTERNATIONAL WORKSHOP
ON MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT AND LEUKEMIA
May 4 - 7, 2014 / Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue / Cincinnati, OH 45229
ABOUT
Since 1995, the Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia has offered a highly successful presentation series from approximately 40-50 renowned national and international researchers and clinicians.
The goal of these biennial workshops is to bring together investigators with expertise in complementary aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemia and myelodysplastic/myeloproliferative syndromes. Basic researchers and clinician investigators from both sides of the Atlantic, Australia, and Japan come together biennially to discuss their latest findings in a close and informal setting. The workshop brings together scientists with expertise in normal and abnormal hematopoiesis and clinicians who treat leukemia/MDS/MPD patients and also have active research programs in these diseases.
Participants achieve a better understanding of critical steps/factors that regulate hematopoiesis, their impact on leukemogenesis, and their potential relevance in clinical settings. Although there are other workshops and meetings dedicated to understanding the regulation of hematopoiesis or clinical advances in leukemia, this workshop uniquely brings together both clinicians and scientists in a relaxed forum.
SPEAKERS
Aifantis, Iannis
New York University Medical Center
Aplan, Peter
NCI
Bernstein, Irv
Fred Hutchinson Cancer Research Center
Cancelas, Jose
Cincinnati Children's Hospital & Hoxworth Blood Center
Carroll, Martin
University of Pennsylvania
Castilla, Lucio
University of Massachusetts
Corey, Seth
Northwestern University
Crispino, John
Northwestern University
Delwel, Ruud
Erasmus MC
Figueroa, Maria
University of Michigan
Friedman, Alan
Johns Hopkins Medical Institute
Geiger, Hartmut
University of Ulm/Cincinnati Children's Hospital
Goldfarb, Adam
University of Virginia
Goodell, Margaret
Baylor College of Medicine
Grimes, H. Leighton
Cincinnati Children's Hospital
Hess, Jay
Indiana University
Hiebert, Scott
Vanderbilt University
Horwitz, Marshall
University of Washington
Izraeli, Shai
Sheba Medical Center
Jordan, Craig
Univ. of Colorado Denver
Keller, Jonathan
NCI
Klusmann, Jan-Henning
Hannover Medical School
Kogan, Scott
University of California San Francisco
Krause, Diane
Yale University
Langdon, Wallace York
University of Western Australia
Levine, Ross
Memorial Sloan-Kettering Cancer Center
Liebermann, Dan
Temple University
Link, Daniel
Washington University in Saint Louis
Liu, Paul
NHGRI
Melnick, Ari
Cornell University
Mulloy, James
Cincinnati Children's Hospital
Nakamura, Takuro
The Cancer Institute of JFCR
Ness, Scott
University of New Mexico
Nimer, Stephen
University of Miami Medical System
Park, Christopher
Memorial Sloan-Kettering Cancer Center
Passegue, Emmanuelle
University of California San Francisco
Rosmarin, Alan
Umass Memorial Medical Center
Shimamura, Akiko
Fred Hutchinson Cancer Research Center
Singh, Harinder
Cincinnati Children's Hospital
Tenen, Daniel
Harvard University
Touw, Ivo
Erasmus MC
Wang, Qian-fei "Jeffrey"
Beijing Institute of Genomics
Zhang, Dong-Er
University of California San Diego
AGENDA
SUNDAY MAY 4TH
UNIVERSITY OF CINCINNATI KRESGE AUDITORIUM
231 ALBERT SABIN WAY
CINCINNATI, OH 45267
Signaling and Transcription in Normal and Malignant Hematopoiesis
Co-Chairs: James Mulloy and Scott Hiebert
2:30 PM
Liebermann
"Gadd45 Stress Sensors in Malignancy and Leukemia”
3:00 PM
Ness
"Mechanisms regulating and activating the Myb oncogene"
3:30 PM
Castilla
"Targeted therapies for inv16 AML”
4:00 PM
Mulloy
"CBL restricts the myeloid proliferation of human AML1-ETO preleukemia cells”
4:30 PM
Hiebert
"Targeting transcription elongation in acute myeloid leukemia”
5:00 PM
Friedman
"A Src to Runx1 to C/EBPa Pathway Regulating Granulopoiesis”
5:30 PM
Zhang
"RUNX1, SRSF2, and their related alternative RNA splicing in hematopoiesis”
6:00 PM
Delwel
"A single oncogenic enhancer-rearrangement causes concomitant deregulation of EVI1 and GATA2 in leukemia”
6:30 PM
Langdon
"Dasatinib activates quiescent hematopoietic stem cells in c-Cbl RING finger mutant and wild-type mice"
7:00 PM
"RUB MY BELLY: A CULINARY misADVENTURE IN THE ORIENT" CCHMC S1.203-204
Open Bar and Appetizers with music by “Jake Speed and the Freddies”
7:30 PM
Doors open to dinner
9:00 PM
Transportation to the Westin
MONDAY, MAY 5TH
CCHMC S1.203-204
Transcriptional Control of Normal and Malignant Hematopoiesis
Chair: Jay Hess and Dan Tenen
8:30 AM
Aplan
"The NUP98-PHF23 modifies chromatin and causes a wide array of leukemias that are sensitive to inhibition of a Ph.D. domain-H3K4Me3 interaction”
9:00 AM
Nakamura
"The role of Sytl1, a downstream target of Meis1, in myeloid leukemogenesis”
9:30 AM
Hess
"Role of Myeloid Transcription Factors in Transformation by HOXA9"
10:00 AM
Wang
"The Genome and Transcriptome of MLL Leukemia: Biological Insights Beyond the Fusion Pathway”
10:30 AM
BREAK
11:00 AM
Carroll
"Role of FOXO proteins in Primary Human AML Cells"
11:30 AM
Rosmarin
"Role of GABP Transcription Factor in Control of Hematopoietic Stem Cells and Leukemic Stem Cells”
12:00 PM
Tenen
"Myeloid differentiation and leukemia-initiating cell”
12:30 PM
LUNCH "Paleo Option”
Megakaryocyte-Erythroid lineage
Co-Chairs: Diane Krause and Shai Izraeli
1:30 PM
Keller
"The Zinc Finger Protein, Pogz, is Required for Bcl11a-Dependent Embryonic Hemoglobin Expression”
2:00 PM
Krause
"The Biphenotypic Fate Decision of Megakaryocyte-Erythroid Progenitors”
2:30 PM
Goldfarb
"Mechanisms Associated with Defective Megakaryocyte Development in Infants”
3:00 PM
Izraeli
"ERG/GATA transcription factors in mega-erythroid development and leukemia”
3:30 PM
BREAK
4:00 PM
Klusmann
"ncRNA ensembles on human chromosome 11 and 21 promote megakaryopoiesis and leukemogenesis”
4:30 PM
Touw
"Deregulation of miR-139-3p and miR-199a-3p drives leukemic transformation of Fanconi anemia”
5:00 PM
LIGHTNING ROUND OF 5 MIN TALKS SELECTED FROM THE POSTERS
Note: Dr. Tenen is bringing the chicken! (so you will need to keep strictly to your time)
5:00 PM
Huang
Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse.
5:05 PM
Cierpicki
Menin-MLL inhibitors block the oncogenic activity of MLL fusion proteins using mechanisms independent of the translocation partner.
5:10 PM
Pietras
Interleukin-1 Drives Hematopoietic Stem Cell Differentiation Via a Pu.1-Dependent Molecular Circuit.
5:15 PM
Chase
The Trithorax group gene Ash1L regulates quiescence, self-renewal potential, and niche occupancy in adult hematopoietic stem cells.
5:20 PM
Fulkerson
Transcription and promoter profiling of murine eosinophil-lineage commitment.
5:25 PM
Carlesso
Activation of the TLR4-MyD88 pathway impairs HSC function during acute inflammation.
5:30 PM
Filippi
A p190-B/ROS/TGFbeta signaling network instructs hematopoietic stem and progenitor cell fate decisions to self-renew or to differentiate by controlling asymmetric inheritance of activated p38MAPK
5:35 PM
McKinney-Freeman
Functional Screen for Novel Regulators of Hematopoietic Stem Cell Engraftment.
5:40 PM
Meyer
Dissection of OncomiR-196b Function in MLL-AF9 Leukemogenesis Through Functional Screening of miR-196b-RISC Captured Targets.
5:45 PM
Chai
SALL4 Contributes to Leukemogenesis Through Impaired FA-Mediated DNA Damage Repair.
5:50 PM
Pan
Novel Role of Tet2 in DNA-mismatch Repair Through Interaction with MSH6, Which is Critical for Tet2 Loss-Mediated Hematologic Malignancies.
5:55 PM
Muntean
Mutated Ptpn11 Alters Leukemic Stem Cell Frequency and Desensitizes Acute Myeloid Leukemia Cells to Mcl1 Inhibition.
6:00 PM
TRANSPORTATION TO THE AMERICAN SIGN MUSEUM
1330 Monmouth Avenue, Cincinnati, OH 45225 (Camp Washington neighborhood of Cincinnati)
7:00 PM - 7:45 PM
"JERUSALEM: BIG BAND MEETS HOLY LAND"
Open Bar and Appetizers with music by “Different Hats” 18-piece Orchestra
7:45 PM - 8:45 PM
Dinner
8:45 PM - 9:15 PM
Dessert and Coffee
9:15 PM
Transportation to the Westin
TUESDAY, MAY 6TH
CCHMC S1.203-204
Hematopoietic Stem Cells
Co-Chairs: Peggy Goodell and Iannis Aifantis
8:30 AM
Aifantis
"Cytosine hydroxy-methylating enzymes in the control of hematopoiesis and leukemogenesis”
9:00 AM
Nimer
"The role of arginine methyltransferases in normal and malignant hematopoiesis”
9:30 AM
Goodell
"Regulation of normal and malignant hematopoiesis by DNA methylation”
10:00 AM
Geiger
"Aging of HSCs, polarity and division”
10:30 AM
BREAK
11:00 AM
Starczynowski
"Novel mechanism of HSC regulation by TRAF6 in MDS”
11:30 AM
Passegue
"Normal and abnormal hematopoiesis: lessons learned from CML development”
12:00 PM
Berstein
"Quantitative differences in Notch signal strength determine hematopoietic stem cell fate”
12:30 PM
LUNCH "The One and Only Club”
Marrow Failure Syndromes and Myelopoiesis
Co-Chairs: Akiko Shimamura and Scott Kogan
1:30 PM
Link
"Regulation of Stem Cell Niches by G-CSF”
2:00 PM
Shimamura
"Marrow Failure and MDS: Lessons from Inherited Syndromes”
2:30 PM
Horwitz
"Translational Control of Neutrophil Elastase in Congenital Neutropenia”
3:00 PM
Cancelas
"Myelopoiesis from induced pluripotent stem cells reveals novel pathogenetic and pharmacological insights in severe congenital neutropenia”
3:30 PM
Kogan
"Understanding the Promyelocyte”
4:30 PM
Aronow
"Network Analysis of Single Cell Programming”
4:40 PM
Grimes
"Utility of Single Cell Analysis To Dissect Lineage Fate Decisions”
5:05 PM
Singh
"Revisiting the transcriptional control of myeloid versus B cell fate choice”
5:30 PM
TRANSPORTATION TO THE WESTIN FOR POSTER SESSION
6:15 PM - 8:00 PM
POSTER SESSION/ ITALIAN WINE + ANTIPASTO- WESTIN HOTEL - TYLER DAVIDSON ROOM -
8:00 PM
DINNER ON YOUR OWN
WEDNESDAY, MAY 7TH
CCHMC S1.203-204
Epigenetics and Translation
Co-Chairs: Ken Figueroa and Craig Jordan
8:30 AM
Corey
"Mathematical Modeling of Clonal Evolution in MDS: A Gain of Clones”
9:00 AM
Figueroa
"Epigenetic deregulation MDS and its impact on response to DNA methyltransferase inhibitors”
9:30 AM
Levine
"Epigenetic convergence as a mechanism of leukemic transformation”
10:00 AM
Melnick
"Epigenetic basis of AML”
10:30 AM
BREAK
11:00 AM
Park
"Therapeutic Targeting of CD99 in Stem Cells of Myeloid Neoplasms”
11:30 AM
Jordan
"Targeting unique metabolic properties of leukemia stem cells”
12:00 PM
Liu
"Understanding the function of CBFB and RUNX1 in hematopoietic stem cells in zebrafish models"
12:30 PM
Crispino
"Aurora A kinase is a novel therapeutic target in the myeloproliferative neoplasms”
1:00 PM
BOX LUNCH and TRANSPORTATION TO WESTIN OR CVG
SUBMIT ABSTRACT
HOTEL
Westin Hotel & Resorts
21 East Fifth Street
Cincinnati, OH 45202
1 (800) 937-8461
When making your reservation, please state that you are part of the MYELOID WORKSHOP Group; otherwise, the Westin staff will not be able to provide the negotiated rates. The last date to make reservations at the negotiated rate is April 3rd, 2014.
Room Pricing
$169.00 Single/Double
Room occupancy rate plus 17% applicable state and local taxes
SPONSORS
AMERICAN SIGN MUSEUM
Come take a walk down Memory Lane and experience the only public sign museum in America.
Visit the American Sign Museum and find a treasure trove of information relative to the rich tradition of sign fabrication and design. You can also find news of sign preservation efforts throughout the country and even visit the Museum's permanent collection
EXPLORE CINCINNATI
The CAC is one of the first contemporary art institutions in the United States. It is a pioneering contemporary art museum located in Cincinnati, Ohio. The CAC is a non-collecting museum that focuses on new developments in painting, sculpture, photography, and more.
The Cincinnati Art Museum is one of the oldest art museums in the United States. Founded in 1881, it was the first purpose-built art museum west of the Alleghenies. Its collection of over 60,000 works makes it one of the most comprehensive collections in the Midwest.
The Cincinnati Zoo and Botanical Garden is one of the oldest zoos in the United States. It opened in 1875, just 14 months after the Philadelphia Zoo on July 1st, 1874. The Reptile House is the oldest zoo building in the United States, dating from 1875.
Learn about the history of the river, take in a magnificent meal, or dance under the stars on an unbelievable journey you will never forget. BB Riverboats offers a wide variety of cruises, ranging from lunch and dinner cruises to sightseeing cruises and all-day mini vacations.
The Cincinnati Museum Center at Union Terminal is a passenger railroad station in the Queensgate neighborhood of Cincinnati. After the decline of railroad travel, most of the building was converted to other uses, and now houses museums, theaters, and more.
Fountain Square attracts over 2 million people annually to its special events, free concerts, tailgates, and lunchtime contests. It’s a place to meet friends for morning coffee or gather for lunch. A place to learn about Cincinnati's history and begin or end your evening downtown.
CONTACT
Kristie Gilb
Logistics
Phone: (513) 636-9445
Email: [email protected]
H. Leighton Grimes, Ph.D.
Meeting Organizer
Phone: (513) 636-6089
Email: [email protected]