Transportation from the 21c Museum Hotel
CCHMC S1.203-204
EPIGENETICS
Chairs: James C. Mulloy and Maria E. Figueroa
Expression of a NUP98-HOXD13 fusion gene and IDH2 R140Q mutant leads to early T-cell precursor (ETP) leukemia
Peter D. Aplan
NCI/NIH
Polycomb repressive complexes in hematological malignancies
Atsushi Iwama
Chiba University, Japan
A Faithful In Vivo Model of Human MLL-AF4 pro-B Acute Lymphoblastic Leukemia
James C. Mulloy
Cincinnati Children’s Hospital Medical Center
Applying lessons learned from inherited forms of leukemia in order to treat ALL: Addressing haploinsuffinciency of PAX5 through activation of functionally equivalent gene family members
Marshall Horwitz
University of Washington, Seattle
High Resolution Mapping of Active RNA Polymerases Defines the Mechanism of Action of Chromatin Regulators in t(8;21) AML
Scott W. Hiebert
Vanderbilt University
Role of mutations in epigenetic regulators in pathogenesis of myeloid malignancies
Ross Levine
Memorial Sloan Kettering
Dnmt3a in Hematopoietic Stem Cells, Cancer and Aging
Margaret A. Goodell
Baylor College of Medicine
Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia
Sara E. Meyer
Cincinnati Children’s Hospital Medical Center
The role of 5-hydroxymethylcytosine in epigenetic regulation of myelodysplastic syndromes
Maria E. Figueroa
University of Michigan
TARGETS IN HEMATOLOGIC MALIGNANCIES
Chair: Patricia Ernst
MUSASHI-2 and the RNA binding network in myeloid leukemia
Michael Kharas
Memorial Sloan Kettering
Transcriptional Dysregulation in Pre-Leukemic Stem Cells and their Progression to MDS and AML
Ulrich Steidl
Albert Einstein College of Medicine
Core circadian clock genes regulate leukemia stem cells in AML
Benjamin Ebert
Harvard Medical School
Requirement for endogenous histone methyltransferases in MLL-fusion leukemia
Patricia Ernst
University of Colorado
Diverse Effects of FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia
Martin Carroll
University of Pennsylvania
LIGHTNING ROUND: rapid fire 4 minute talks with one slide (selected from the posters)
Chair: Dan Tenen (and a rubber chicken)
Daniel Lucas-Alcoraz
Bone marrow granulocytes drive hematopoietic and vascular regeneration
Karen Sue Carlson
Extracellular Matrix Homeostasis Can Regulate Steady-State Hematopoiesis
Joseph Fisher
The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA9
Hironori Harada
Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes
Jan Henning Klusmann
Integrated Analysis of the Human Hematopoietic Non-Coding RNA Landscape Reveals Lnc-RNA Stem Cell Signature in AML
Scott Kogan
A tumor suppressive role of IRF8 in acute promyelocytic leukemia
Ivan Maillard
Ash1l, the mammalian homologue of a Trithorax group gene, controls hematopoietic stem cell homeostasis independently of its methyltransferase activity
Andrew Munteen
Differential regulation of c-Myc/Lin28 discriminates subclasses of rearranged MLL leukemia
Tobias Neff
The Role of Gata2 in Murine Models of Acute Myeloid Leukemia
David Sykes
Small molecule inhibitors of the enzyme dihydroorotate dehydrogenase overcome differentiation blockade in acute myeloid leukemia
Michael Thirman
Transducible MLL peptide exhibits significant activity in combination with DOT1L and CDK9 inhibitors
Jennifer Trowbridge
Acute Myeloid Leukemia (AML) Cell-of-Origin Identified by Chromatin Landscape of Bulk Tumor Cells
Transportation to the American Sign Museum
Cirque; an Oscar party without the movies Dinner Event
1330 Monmouth Avenue, Cincinnati OH 45225 (Camp Washington neighborhood of Cincinnati)
6:45 PM - 7:45 PM Open Bar and Appetizers
7:45 PM - 8:45 PM Dinner
8:45 PM - 9:15 PM Dessert and Coffee
9:15 PM Transportation to the 21c Museum Hotel
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
HEMATOPOIETIC DIFFERENTIATION AND LINEAGE COMMITMENT
Chair: Harinder Singh
Role of the +37 kb Cebpa Enhancer During Hematopoiesis and Myeloid Transformation
Alan Friedman
Johns Hopkins University
An exclusive CEBPA enhancer for myeloid-lineage priming and neutrophilic differentiation
Ruud Delwel
ErasmusMC, The Netherlands
Regulation of the tumor suppressor CEBPA by noncoding RNA
Daniel G. Tenen
Cancer Science Institute of Singapore
An Ontogenic Molecular Switch Controls Human Megakaryocyte Differentiation by Modulating a Specialized P-TEFb Activation Pathway
Adam N. Goldfarb
University of Virginia
Targeting aberrant megakaryopoiesis in primary myelofibrosis
John Crispino
Northwestern University
How do adult human megakaryocyte-erythroid progenitors make their lineage fate decisions?
Diane S. Krause
Functional and transcriptional heterogeneity of human haemopoietic lympho-myeloid progenitor cells
Paresh Vyas
University of Oxford, UK
Shaping the blood: Lessons from Chromatin and single cell RNA dynamics
Ido Amit
Weizmann Institute of Science
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Harinder Singh
Cincinnati Children’s Hospital Medical Center
Transcriptional and chromatin-mediated control of macrophage differentiation and function
Gioacchino Natoli, MD
European Institute of Oncology (IEO), Milan, Italy
Induction of Key Immunoregulatory Genes in Macrophages by Highly Unique Molecular Mechanisms
Stephen T. Smale
UCLA
Cis-Regulatory Mechanisms Governing Hematopoietic Stem and Progenitor Cell Transitions
Emery H. Bresnick
Wisconsin School of Medicine
MARROW FAILURE AND TRANSFORMATION
Chair: Akiko Shimamura
Molecular Aspects of Myeloid Stem Cell Development
Stephen Nimer, MD
Sylvester Comprehensive Cancer Center, University of Miami
Modeling leukemic progression of severe congenital neutropenia (SCN) by genome editing of patient-derived induced pluripotent stem cells
Ivo Touw
Erasmus MC, The Netherlands
Modeling Bone Marrow Failure and MDS in Shwachman Diamond Syndrome using induced Pluripotent Stem Cells
Akiko Shimamura
Boston Children's Cancer
Ineffective erythropoiesis and MDS
Janis Abkowitz
University of Washington, Seattle
sbds knockout in zebrafish results in neutropenia, pancreatic atrophy, diminished growth, and reduced viability
Seth J. Corey
Children’s Hospital of Richmond, VA
Transportation to the Contemporary Arts Center
44 E 6th St, Cincinnati, OH 45202
Dinner at the Contemporary Arts Center
España Modernica Dinner Event
6:45 PM - 8:30 PM Open Bar, tapas stations, live Spanish guitar
The museum galleries will be open till 8:00 PM
Docents will be available to answer questions
No food or drinks in the museum gallery space
8:30 PM - 9:00 PM Dessert and Coffee
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
HEMATOPOIETIC STEM CELLS
Chair: Iannis Aifantis
Hijacking of emergency myelopoiesis pathways in myeloid malignancies
Emmanuelle Passegué
UCSF
Gfi1 Contributes to the Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity
Damien Reynaud
Cincinnati Children's Hospital Medical Center
Regulation of hematopoietic stem cell enhancer dynamics by the MEDIATOR complex
Iannis Aifantis
NYU School of Medicine
Control of Dormancy in HSCs by Myc and Retinoic Acid
Andreas Trumpp
German Cancer Research Center
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Leonard I. Zon
Boston Children’s Hospital
Evolution of clonal hematopoiesis following chemotherapy
Daniel C. Link
Washington University in St. Louis
Inherited Predisposition to Myeloid Malignancies
Lucy A. Godley, M.D., Ph.D.
The University of Chicago
Jay Scott, Alex’s Lemonade Stand (short video announcement of a new opportunity)
Alan Mufson, NCI/NIH
John Kanki, Taub Foundation
Michael Lewis, Evans Foundation
Stephen Nimer, Gabrielle’s Angel Foundation
MDS MODELING AND THERAPY
Chair: Daniel Starczynowski
Epistasis of neighboring immune-requisite genes in del(5q) MDS
Daniel Starczynowski, PhD
Cincinnati Children’s Hospital Medical Center
Modeling Therapy-Related Myeloid Neoplasms with a del(5q): Haploinsufficiency of Multiple del(5q) Genes Cooperate with loss of TP53 and Alkylating Agent Therapy
Michelle Le Beau
University of Chicago
Targeting MDS Stem Cell with Novel TLR Selective Therapeutics
Alan F. List
Moffitt Cancer Center
Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model
Stephanie Halene
Yale University
Disease stage-specific human induced pluripotent stem cells (iPSCs) delineate a phenotypic roadmap to myeloid transformation
Eirini P Papapetrou
Mount Sinai, New York
Dissecting the Contribution of Aging to MDS Pathogenesis
Christopher Y. Park
Sloan Kettering
HIF-1α Signaling is a Central Pathobiologic Mediator of Myelodysplastic Syndromes
Gang Huang
Cincinnati Children’s Hospital Medical Center
Targeting the Mutant Spliceosome in MDS
Tim Graubert, MD
Mass General Cancer Center
Transportation to the 21c Museum Hotel
Poster Session
Sponsored by the Evans Foundation
21c Gallery open bar and Dinner-By-The-Bite
Transportation from the 21c Museum Hotel
CCHMC S1.203-204
TARGETING LEUKEMIA
Chairs: Ari Melnick and Craig T. Jordan
Mechanism of BCR-ABL addiction and TKI efficacy
Mohammad Azam
Cincinnati Children’s Hospital Medical Center
Therapeutic Targeting of the Leukemic Stem Cell in Chronic Myelogenous Leukemia and a Novel Approach to Overcome Resistance to Tyrosine Kinase Inhibitors
Alan G. Rosmarin
University of Massachusetts Medical School Worcester
Mechanism of AI-10-49 mediated apoptosis in inv16 AML
Lucio H. Castilla
University of Massachusetts Medical School, Worcester
Gene repression by DNA methylation and LSD1-mediated enhancer inactivation in AML
Ari Melnick
Cornell University
New Targets in High-risk Acute Myeloid Leukemia
Kimberly Stegmaier
Boston Children’s Hospital
Inhibition of Mitochondrial Fission Impairs Leukemia Stem Cell Function in Acute Myelogenous Leukemia
Craig T. Jordan
University of Colorado
Activation of TRIF-dependent signaling causes hematopoietic stem cell exhaustion during sepsis
Nadia Carlesso
Indiana University School of Medicine
Inflammation recruits progenitors directly to lymphatics for dendritic cell replenishment through CCR7 and non-canonical IkB kinase
Jose A. Cancelas
Cincinnati Children’s Hospital Medical Center
Shuttle to the CVG airport
Shuttle to 21c Museum Hotel and then CVG airport
