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Eleventh International Workshop

on molecular aspects of myeloid stem cell development and leukemia

May 2 - 5, 2016
Cincinnati Children's Hospital
Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229

About

Since 1995, the Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia has offered a highly successful presentation series from approximately 40-50 renowned national and international researchers and clinicians.

acute-myeloid-leukemia

The goal of these biennial workshops is to bring together investigators with expertise in complementary aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemias and myelodysplastic/myeloproliferative syndromes. Basic researchers and clinician investigators from both sides of the Atlantic, Australia and Japan come together biennially to discuss their latest findings in a close and informal setting. The workshop brings together scientists with expertise in normal and abnormal hematopoiesis and clinicians who treat leukemia/MDS/MPD patients and also have active research programs in these diseases.

Participants achieve a better understanding of critical steps/factors that regulate hematopoiesis, their impact in leukemogenesis, and potential relevance in clinical settings. Although there are other workshops and meetings dedicated to understanding the regulation of hematopoiesis or clinical advances in leukemia, this workshop uniquely brings together both clinicians and scientists in a relaxed forum.

Speakers

Abkowitz, Jan
Division of Hematology

Aifantis, Iannis
New York University

Amit, Ido
Weizmann Institute, Israel

Aplan, Peter
National Cancer Institute

Azam, Mohammad
Cincinnati Children's Hospital Medical Center

Bresnick, Emery
University of Wisconsin

Cancelas, Jose
Cincinnati Children's Hospital Medical Center

Carlesso, Nadia
Indiana University

Carroll, Martin
University of Pennsylvania

Castilla, Lucio
University of Massachusetts Medical School

Corey, Seth
Northwestern University

Crispino, John
Northwestern University

Delwel, Ruud
Erasmus University, Netherlands

Ebert, Ben
Harvard Medical School

Ernst, Patricia
University of Colorado, Denver

Figueroa, Maria
University of Michigan

Friedman, Alan
Johns Hopkins University

Godley, Lucy
University of Chicago

Goldfarb, Adam
University of Virginia, School of Medicine

Goodell, Margaret A.
Baylor College of Medicine

Graubert, Timothy A.
Massachusetts General Hospital

Grimes, H. Leighton
Cincinnati Children's Hospital Medical Center

Halene, Stephanie
Yale School of Medicine

Hiebert, Scott
Vanderbilt University School of Medicine

Horwitz, Marshall
University of Washington School of Medicine

Huang, Gang
Cincinnati Children's Hospital Medical Center

Iwama, Atsushi
Chiba University, Japan

Jordan, Craig
University of Colorado, Anschutz Medical Campus

Kharas, Michael
Memorial Sloan Kettering

Krause, Diane
Yale University School of Medicine

Le Beau, Michelle
University of Chicago

Link, Daniel
Washington University School of Medicine

List, Alan F.
Moffitt Cancer Center

Levine, Ross
Memorial Sloan Kettering

Melnick, Ari
Weill Cornell Medicine

Mulloy, James
Cincinnati Children's Hospital Medical Center

Natoli, Gioacchino
IFOM-IEO, Italy

Nimer, Stephen
University of Miami School of Medicine

Papapetrou, Eirini
Icahn School of Medicine at Mount Sinai

Park, Chris
Memorial Sloan Kettering

Passegue, Emmanuelle
University of California, San Francisco

Rosmarin, Alan
University of Massachusetts Medical School Worcester

Reynaud, Damien
Cincinnati Children's Hospital Medical Center

Shimamura, Akiko
Fred Hutchinson Cancer Center

Singh, Harinder
Cincinnati Children's Hospital Medical Center

Smale, Stephen
University of California, Los Angeles

Starczynowski, Daniel
Cincinnati Children's Hospital Medical Center

Stegmaier, Kim
Harvard Medical School

Steidl, Uli
Albert Einstein College of Medicine

Tenen, Daniel
Harvard Medical School

Touw, Ivo
Erasmus University, Netherlandsa

Trumpp, Andreas
German Cancer Research Center, Germany

Vyas, Paresh
Radcliffe Department of Medicine

Zon, Leonard
Boston Children's Hospital

Agenda

Monday May 2

7:30 AM

Transportation from the 21c Museum Hotel


CCHMC S1.203-204
EPIGENETICS
Chairs: James C. Mulloy and Maria E. Figueroa


8:00 AM

Expression of a NUP98-HOXD13 fusion gene and IDH2 R140Q mutant leads to early T-cell precursor (ETP) leukemia
Peter D. Aplan
NCI/NIH


8:30 AM

Polycomb repressive complexes in hematological malignancies
Atsushi Iwama
Chiba University, Japan


9:00 AM

A Faithful In Vivo Model of Human MLL-AF4 pro-B Acute Lymphoblastic Leukemia
James C. Mulloy
Cincinnati Children’s Hospital Medical Center


9:30 AM

Applying lessons learned from inherited forms of leukemia in order to treat ALL: Addressing haploinsuffinciency of PAX5 through activation of functionally equivalent gene family members
Marshall Horwitz
University of Washington, Seattle


10:00 AM

High Resolution Mapping of Active RNA Polymerases Defines the Mechanism of Action of Chromatin Regulators in t(8;21) AML
Scott W. Hiebert
Vanderbilt University


10:30 AM

Break


11:00 AM

Role of mutations in epigenetic regulators in pathogenesis of myeloid malignancies
Ross Levine
Memorial Sloan Kettering


11:30 AM

Dnmt3a in Hematopoietic Stem Cells, Cancer and Aging
Margaret A. Goodell
Baylor College of Medicine


12:00 PM

Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia
Sara E. Meyer
Cincinnati Children’s Hospital Medical Center


12:30 PM

The role of 5-hydroxymethylcytosine in epigenetic regulation of myelodysplastic syndromes
Maria E. Figueroa
University of Michigan


1:00 PM


TARGETS IN HEMATOLOGIC MALIGNANCIES
Chair: Patricia Ernst


2:00 PM

MUSASHI-2 and the RNA binding network in myeloid leukemia
Michael Kharas
Memorial Sloan Kettering


2:30 PM

Transcriptional Dysregulation in Pre-Leukemic Stem Cells and their Progression to MDS and AML
Ulrich Steidl
Albert Einstein College of Medicine


3:00 PM

Core circadian clock genes regulate leukemia stem cells in AML
Benjamin Ebert
Harvard Medical School


3:30 PM


4:00 PM

Requirement for endogenous histone methyltransferases in MLL-fusion leukemia
Patricia Ernst
University of Colorado


4:30 PM

Diverse Effects of FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia
Martin Carroll
University of Pennsylvania


5:00 PM

LIGHTNING ROUND: rapid fire 4 minute talks with one slide (selected from the posters)
Chair: Dan Tenen (and a rubber chicken)

Daniel Lucas-Alcoraz
Bone marrow granulocytes drive hematopoietic and vascular regeneration

Karen Sue Carlson
Extracellular Matrix Homeostasis Can Regulate Steady-State Hematopoiesis

Joseph Fisher
The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of HoxA9

Hironori Harada
Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes

Jan Henning Klusmann
Integrated Analysis of the Human Hematopoietic Non-Coding RNA Landscape Reveals Lnc-RNA Stem Cell Signature in AML

Scott Kogan
A tumor suppressive role of IRF8 in acute promyelocytic leukemia

Ivan Maillard
Ash1l, the mammalian homologue of a Trithorax group gene, controls hematopoietic stem cell homeostasis independently of its methyltransferase activity

Andrew Munteen
Differential regulation of c-Myc/Lin28 discriminates subclasses of rearranged MLL leukemia

Tobias Neff
The Role of Gata2 in Murine Models of Acute Myeloid Leukemia

David Sykes
Small molecule inhibitors of the enzyme dihydroorotate dehydrogenase overcome differentiation blockade in acute myeloid leukemia

Michael Thirman
Transducible MLL peptide exhibits significant activity in combination with DOT1L and CDK9 inhibitors

Jennifer Trowbridge
Acute Myeloid Leukemia (AML) Cell-of-Origin Identified by Chromatin Landscape of Bulk Tumor Cells


6:15 PM

Transportation to the American Sign Museum
Cirque; an Oscar party without the movies Dinner Event
1330 Monmouth Avenue, Cincinnati OH 45225 (Camp Washington neighborhood of Cincinnati)

6:45 PM - 7:45 PM Open Bar and Appetizers
7:45 PM - 8:45 PM Dinner
8:45 PM - 9:15 PM Dessert and Coffee
9:15 PM Transportation to the 21c Museum Hotel


Tuesday May 3

7:30 AM

Transportation from the 21c Museum Hotel


CCHMC S1.203-204
HEMATOPOIETIC DIFFERENTIATION AND LINEAGE COMMITMENT
Chair: Harinder Singh

8:00 AM

Role of the +37 kb Cebpa Enhancer During Hematopoiesis and Myeloid Transformation
Alan Friedman
Johns Hopkins University


8:30 AM

An exclusive CEBPA enhancer for myeloid-lineage priming and neutrophilic differentiation
Ruud Delwel
ErasmusMC, The Netherlands


9:00 AM

Regulation of the tumor suppressor CEBPA by noncoding RNA
Daniel G. Tenen
Cancer Science Institute of Singapore


9:30 AM

An Ontogenic Molecular Switch Controls Human Megakaryocyte Differentiation by Modulating a Specialized P-TEFb Activation Pathway
Adam N. Goldfarb
University of Virginia


10:00 AM

Targeting aberrant megakaryopoiesis in primary myelofibrosis
John Crispino
Northwestern University


10:30 AM

Break


11:00 AM

How do adult human megakaryocyte-erythroid progenitors make their lineage fate decisions?
Diane S. Krause


11:30 AM

Functional and transcriptional heterogeneity of human haemopoietic lympho-myeloid progenitor cells
Paresh Vyas
University of Oxford, UK


12:00 PM

Shaping the blood: Lessons from Chromatin and single cell RNA dynamics
Ido Amit
Weizmann Institute of Science


12:30 PM

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Harinder Singh
Cincinnati Children’s Hospital Medical Center


1:00 PM


2:00 PM

Transcriptional and chromatin-mediated control of macrophage differentiation and function
Gioacchino Natoli, MD
European Institute of Oncology (IEO), Milan, Italy


2:30 PM

Induction of Key Immunoregulatory Genes in Macrophages by Highly Unique Molecular Mechanisms
Stephen T. Smale
UCLA


3:00 PM

Cis-Regulatory Mechanisms Governing Hematopoietic Stem and Progenitor Cell Transitions
Emery H. Bresnick
Wisconsin School of Medicine


MARROW FAILURE AND TRANSFORMATION
Chair: Akiko Shimamura


3:30 PM

Molecular Aspects of Myeloid Stem Cell Development
Stephen Nimer, MD
Sylvester Comprehensive Cancer Center, University of Miami


4:00 PM

Modeling leukemic progression of severe congenital neutropenia (SCN) by genome editing of patient-derived induced pluripotent stem cells
Ivo Touw
Erasmus MC, The Netherlands


4:30 PM


5:00 PM

Modeling Bone Marrow Failure and MDS in Shwachman Diamond Syndrome using induced Pluripotent Stem Cells
Akiko Shimamura
Boston Children's Cancer


5:30 PM

Ineffective erythropoiesis and MDS
Janis Abkowitz
University of Washington, Seattle


6:00 PM

sbds knockout in zebrafish results in neutropenia, pancreatic atrophy, diminished growth, and reduced viability
Seth J. Corey
Children’s Hospital of Richmond, VA


6:30 PM

Transportation to the Contemporary Arts Center
44 E 6th St, Cincinnati, OH 45202


6:45 PM

Dinner at the Contemporary Arts Center
España Modernica Dinner Event

6:45 PM - 8:30 PM Open Bar, tapas stations, live Spanish guitar
The museum galleries will be open till 8:00 PM
Docents will be available to answer questions
No food or drinks in the museum gallery space
8:30 PM - 9:00 PM Dessert and Coffee


Wednesday May 4

7:30 AM

Transportation from the 21c Museum Hotel


CCHMC S1.203-204
HEMATOPOIETIC STEM CELLS
Chair: Iannis Aifantis


8:00 AM

Hijacking of emergency myelopoiesis pathways in myeloid malignancies
Emmanuelle Passegué
UCSF


8:30 AM

Gfi1 Contributes to the Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity
Damien Reynaud
Cincinnati Children's Hospital Medical Center


9:00 AM

Regulation of hematopoietic stem cell enhancer dynamics by the MEDIATOR complex
Iannis Aifantis
NYU School of Medicine


9:30 AM

Control of Dormancy in HSCs by Myc and Retinoic Acid
Andreas Trumpp
German Cancer Research Center


10:00 AM

Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment
Leonard I. Zon
Boston Children’s Hospital


10:30 AM

Break


11:00 AM

Evolution of clonal hematopoiesis following chemotherapy
Daniel C. Link
Washington University in St. Louis


11:30 AM

Inherited Predisposition to Myeloid Malignancies
Lucy A. Godley, M.D., Ph.D.
The University of Chicago


FUNDING NEWS


12:00 PM

Jay Scott, Alex’s Lemonade Stand (short video announcement of a new opportunity)
Alan Mufson, NCI/NIH
John Kanki, Taub Foundation
Michael Lewis, Evans Foundation
Stephen Nimer, Gabrielle’s Angel Foundation


12:30 PM


MDS MODELING AND THERAPY
Chair: Daniel Starczynowski


1:30 PM

Epistasis of neighboring immune-requisite genes in del(5q) MDS
Daniel Starczynowski, PhD
Cincinnati Children’s Hospital Medical Center


2:00 PM

Modeling Therapy-Related Myeloid Neoplasms with a del(5q): Haploinsufficiency of Multiple del(5q) Genes Cooperate with loss of TP53 and Alkylating Agent Therapy
Michelle Le Beau
University of Chicago


2:30 PM

Targeting MDS Stem Cell with Novel TLR Selective Therapeutics
Alan F. List
Moffitt Cancer Center


3:00 PM

Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model
Stephanie Halene
Yale University


3:30 PM


4:00 PM

Disease stage-specific human induced pluripotent stem cells (iPSCs) delineate a phenotypic roadmap to myeloid transformation
Eirini P Papapetrou
Mount Sinai, New York


4:30 PM

Dissecting the Contribution of Aging to MDS Pathogenesis
Christopher Y. Park
Sloan Kettering


5:00 PM

HIF-1α Signaling is a Central Pathobiologic Mediator of Myelodysplastic Syndromes
Gang Huang
Cincinnati Children’s Hospital Medical Center


5:30 PM

Targeting the Mutant Spliceosome in MDS
Tim Graubert, MD
Mass General Cancer Center


6:00 PM

Transportation to the 21c Museum Hotel


6:30 PM - 8:30 PM

Poster Session
Sponsored by the Evans Foundation
21c Gallery open bar and Dinner-By-The-Bite


Thursday May 5

7:30 AM

Transportation from the 21c Museum Hotel


CCHMC S1.203-204
TARGETING LEUKEMIA
Chairs: Ari Melnick and Craig T. Jordan


8:00 AM

Mechanism of BCR-ABL addiction and TKI efficacy
Mohammad Azam
Cincinnati Children’s Hospital Medical Center


8:30 AM

Therapeutic Targeting of the Leukemic Stem Cell in Chronic Myelogenous Leukemia and a Novel Approach to Overcome Resistance to Tyrosine Kinase Inhibitors
Alan G. Rosmarin
University of Massachusetts Medical School Worcester


9:00 AM

Mechanism of AI-10-49 mediated apoptosis in inv16 AML
Lucio H. Castilla
University of Massachusetts Medical School, Worcester


9:30 AM

Gene repression by DNA methylation and LSD1-mediated enhancer inactivation in AML
Ari Melnick
Cornell University


10:00 AM

Break


10:30 AM

New Targets in High-risk Acute Myeloid Leukemia
Kimberly Stegmaier
Boston Children’s Hospital


11:00 AM

Inhibition of Mitochondrial Fission Impairs Leukemia Stem Cell Function in Acute Myelogenous Leukemia
Craig T. Jordan
University of Colorado


INFLAMMATION


11:30 AM

Activation of TRIF-dependent signaling causes hematopoietic stem cell exhaustion during sepsis
Nadia Carlesso
Indiana University School of Medicine


12:00 PM

Inflammation recruits progenitors directly to lymphatics for dendritic cell replenishment through CCR7 and non-canonical IkB kinase
Jose A. Cancelas
Cincinnati Children’s Hospital Medical Center


12:30 PM


1:30 PM

Shuttle to the CVG airport


2:00 PM

Shuttle to 21c Museum Hotel and then CVG airport


Submit Abstract

  • All abstracts should follow the ASH (American Society of Hematology) format guidelines.
  • All abstracts should be submitted in Arial, 11 point font with one inch margins all around.
  • Posters should be 3ft x 6ft.
  • All abstracts must be submitted by April 1, 2016.
  • Email abstracts to Kristie Gilb at kristie.gilb@cchmc.org.

Hotel

21c Museum Hotel Cincinnati
609 Walnut Street
Cincinnati, Ohio 45202
513.578.6600

When making your reservation, please state that you are part of the MYELOID WORKSHOP Group; otherwise the 21c staff will not be able to provide the negotiated rates. The last date to make reservations at the negotiated rate is Thursday, March 31, 2016.

Room Pricing
$189.00 Single/Double
Room occupancy rate plus 17.5% applicable state and local taxes.

Reserve Your Room

Visit Website

Sponsors

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cchmc-cancer-and-blood-diseases-institute
cchmc-department-of-pathology
gabrielles-angel-foundation
epe-foundation
taub

American Sign Museum

Come take a walk down Memory Lane and experience the only public sign museum in America. Visit the American Sign Museum and find a treasure trove of information relative to the rich tradition of sign fabrication and design. You can also find news of sign preservation efforts throughout the country and even visit the Museum's permanent collection.

Visit Website

Explore Cincinnati

contemporary-arts-center

Contemporary Arts Center
The CAC is one of the first contemporary art institutions in the United States. It is a pioneering contemporary art museum located in Cincinnati, Ohio. The CAC is a non-collecting museum that focuses on new developments in painting, sculpture, photography and more.

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cincinnati-art-museum

Cincinnati Art Museum
The Cincinnati Art Museum is one of the oldest art museums in the United States. Founded in 1881, it was the first purpose-built art museum west of the Alleghenies. Its collection of over 60,000 works make it one of the most comprehensive collections in the Midwest.

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cincinnati-zoo-and-botanical-garden

Cincinnati Zoo and Botanical Garden
The Cincinnati Zoo and Botanical Garden is one of the oldest zoos in the United States. It opened in 1875, just 14 months after the Philadelphia Zoo on July 1, 1874. The Reptile House is the oldest zoo building in the United States, dating from 1875.

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bb-riverboats

BB Riverboats
Learn about the history of the river, take in a magnificent meal, or dance under the stars on an unbelievable journey you will never forget. BB Riverboats offers a wide variety of cruises ranging from lunch and dinner cruises to sightseeing cruises and all-day mini vacations.

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cincinnati-museum-center

Cincinnati Museum Center
The Cincinnati Museum Center at Union Terminal, is a passenger railroad station in the Queensgate neighborhood of Cincinnati. After the decline of railroad travel, most of the building was converted to other uses, and now houses museums, theaters and more.

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Fountain Square
Fountain Square attracts over 2 million people annually to its special events, free concerts, tailgates, and lunchtime contests. It’s a place to meet friends for morning coffee, or gather for lunch. A place to learn about Cincinnati history and begin, or end, your evening downtown.

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Contact

Scientific Issues
H. Leighton Grimes PhD
Phone: 513.636.6089
Email: lee.grimes@cchmc.org

Logistic Issues
Kristie Gilb
Phone: 513.636.9445
Email: kristie.gilb@cchmc.org

Danielle Davis
Phone: 513.636.1773
Email: danielle.davis@cchmc.org